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A 57 year old woman has coronary heart disease and diabetes. She takes Metformin and Gliclazide for her diabetes but diabetic control is not good. She does not want to start insulin. Would you like to add Pioglitazone or Rosiglitazone to her diabetes treatment in order to reduce the plasma glucose?

  1. Yes, the Thiazolidinediones are useful drugs in reducing plasma glucose.
  2. No, it might be risky to prescribe a Thiazolidinedione for her.

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