7 A

Metformin increases the risk of contrast induced nephropathy and should be stopped 48 hours before any procedure that involves the use of intravenous contrast and should not be restarted until one is certain that contrast-induced nephropathy has not occurred.

Contrast induced nephropathy is defined as a 25 percent increase in serum creatinine from the baseline (or an increase of 44umol/L <0.5mg per dL> in the serum creatinine).

Reference: New England Journal of Medicine

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